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Friday, January 28, 2022

Lessons learned from the 1918 Spanish flu Pandemic

 


What was life like in Minnesota during 

           the flu pandemic of 1918?

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Entering the third year of a deadly pandemic may have some Minnesotans wondering how things could possibly be worse. The final months of 1918 provide a sobering answer.

An influenza pandemic began ravaging the state in the fall of that year — ultimately killing more than 10,000 Minnesotans. Meanwhile, young men were being sent off to a bloody world war overseas and wildfires were destroying entire cities in northern Minnesota.

Reader Sarah Rasmussen moved into a 1917 Minneapolis home just before COVID-19 and realized they were not the first family to endure a pandemic within its walls. She wondered what life was like for those people a century ago.

"They may not have set up a small gym in the basement, but maybe they saw friends in the backyard," Rasmussen wrote in an e-mail.

She sought answers about life in Minnesota during the 1918 pandemic — and how it compares to today — from Curious Minnesota, the Star Tribune's reporting project fueled by great reader questions.

The deadly disease that began killing thousands in 1918 likely originated in Kansas, based on modern research. It quickly earned the nickname "Spanish influenza" because Spain was a neutral country in World War I and did not censor reports about the illness. After cropping up in military camps, it spread quickly due to the proximity and movement of troops during the war, according to the Centers for Disease Control and Prevention.

By the fall, social activities in Minnesota ground to a halt much as they did in spring 2020. Some cities shut down schools and canceled large events. Police broke up crowds in local saloons. The University of Minnesota delayed opening for the fall semester.

"All the towns and cities for miles around are closed — everything but the meat markets, grocery and dry good stores," a young woman, LaVerne Roquette, wrote to her boyfriend overseas in October 1918. "At some places people have to wear gauze masks when they appear on the streets. … The government has closed all schools, churches, theatres."

"That was written 104 years ago, but could have been yesterday," said Curt Brown, author of "Minnesota 1918: When Flu, Fire and War Ravaged the State." A former Star Tribune reporter, Brown still writes a weekly history column for the newspaper.

Not everyone appreciated the precautions.

Dr. H.M. Bracken, executive officer of the state board of health, was vociferously opposed to the school and business closures in Minneapolis.

"If you begin to close, where are you going to stop? When are you going to reopen and what do you accomplish by opening?" Bracken told the Minneapolis City Council in October 1918. "Thus far, St. Paul has seen fit to follow my advice."

About 10 days later, citing a surge in cases, St. Paul followed Minneapolis in shuttering everything from churches and schools to soda fountains and bowling alleys.

Even government agencies were sparring over the new rules. The Minneapolis School Board tried to defy the city Health Department's closure order. The health commissioner responded by ordering the chief of police to close all school buildings and arrest anyone who tried to interfere. The schools, which had opened for half a day, were quickly closed again.

Poorly understood disease

The differences between the two pandemics largely outweigh the similarities, however, starting with the basic standards of living at the time. Cars were still a luxury item and home electricity wasn't guaranteed — particularly in rural areas.

"No one had radios in their homes. … They weren't getting barraged with total case numbers and death counts on social media and TV and radio," Brown said. "It was more word of mouth."

In Minneapolis, mail carriers and Boy Scouts were dispatched to homes and businesses to deliver placards and literature on the spread of influenza. Newspapers offered regular guidance, but there was limited understanding of the disease.

"Scientifically, they didn't even know what the influenza virus was until 1933," Brown said. "They thought it was bacteria."

The Minneapolis City Council ordered that the street commissioners "sprinkle and flush" the streets with water, because "the bacillus of Spanish influenza lurked in the dust of the streets," according to a Minneapolis Morning Tribune article from October 1918.

Some advice is familiar today. The assistant dean of the University of Minnesota medical school, Dr. Richard Beard, said at the time that the disease passed through particles "distributed by mouth or nose spray." To set an example, the Minneapolis Health Department eliminated the use of shared drinking cups and towels — and banned sneezing in the workplace.

The importance of fresh air was regularly stressed. Beard advised that people should open streetcar windows, work in ventilated offices, avoid crowded places and "sleep as nearly as possible out of doors."

Hospitals overrun

Within weeks of the first case reported in Minneapolis, hospitals were overrun. U.S. Surgeon General Rupert Blue chastised the general public for relying too heavily on modern medical care.

"The present generation has been spoiled by having had expert medical and nursing care readily available," Blue said. "I believe the public generally ... has not interested itself sufficiently in studying the home care of the sick."

Testing wasn't available and treatment options were limited to prevention. It would be several decades before an influenza vaccine was available.

"There were no intensive care units or respirators," Brown said. "Death from disease was less of a mind-blow than it is today. I think they were used to people dying of diseases like diphtheria and smallpox."

Nursing staffs were stretched thin by the double crises of flu and war. Ambulances and hospitals in many cities were dedicated almost entirely to flu patients.

In early November 1918, half the nurses at the City Hospital (now HCMC) in Minneapolis were out sick with influenza, and substitutes were hard to find since many were helping the war effort or wildfire victims. Sailors from a naval training station in Illinois were called in to attend flu patients in Minneapolis.

Another place flu found fertile ground to spread was in the temporary housing set up for evacuees of the wildfires in northern Minnesota, says Brown. Historic wildfires in 1918 decimated entire cities and burned people and animals alive. Those who escaped the fast-moving blazes were packed into cramped housing or crowded hospitals.

'Trifecta of woe'

The flu lingered through 1919 and into 1920, though it claimed the majority of its victims at the end of 1918. As with our current pandemic, it came in waves that spurred lockdowns and subsequent re-openings.

When a shutdown was lifted in Minneapolis in November 1918, the Minneapolis Tribune reported that crowds quickly jammed movie theaters and dance halls.

"The passing throngs ... hesitated, still uncertain as to whether or not one huge joke was in the process of being perpetrated, walked up to the cashier's cage, and then, satisfied that it was all true, entered joyously," the Tribune reported about a movie theater.

Roughly 12,000 Minnesotans ultimately died from the illness, Brown said, which is slightly more than have died so far from COVID-19. But Minnesota's population was less than half its current size, so proportionately the death toll was much larger. And unlike other outbreaks, an unusual number of healthy young adults succumbed to the 1918 flu.

"Then you throw on this huge forest fire in the fall and the guys serving in World War I," Brown said, "it was a trifecta of woe."

Wednesday, January 26, 2022

The University of Minnesota is doing trials to see if Invermetin is effective in treating Covid-19

It is too bad they couldn't have done this sooner instead of blaming this as a conspiracy theory. It just might have saved millions of lives.


 CORONAVIRUS 600139471

University of Minnesota ivermectin trial nearing completion

Proof of effectiveness would give doctors outpatient COVID-19 therapies amid limited antiviral and antibody supplies. 

University of Minnesota researchers expect to finish enrollment this week in the nation's first clinical trial of ivermectin to treat COVID-19, and the study's highly anticipated results could be only a month away.

The COVID-OUT study is reviewing three common drugs, including the antidepressant fluvoxamine and the diabetes treatment metformin, but gained attention for its inclusion of ivermectin. The controversial drug has been championed by opponents of COVID-19 vaccines, despite a warning from the Food and Drug Administration (FDA) that ivermectin is cleared only to treat parasitic infections, head lice and certain skin conditions.

Anti-inflammatory benefits of all three medications prompted the U study, which was delayed by slow enrollment over the summer until the delta and omicron waves of the pandemic emerged. Lead researcher Dr. Carolyn Bramante said the results will provide clinical guidance to doctors who are facing record pandemic cases and to the FDA about whether to authorize the drugs for treatment of COVID-19.

"Sooner would have been better, but I'm really proud of my team," she said. "We will be done very quickly."

Proven outpatient COVID-19 treatments have been limited, and supplies in Minnesota have been scarce. Providers in the state discontinued two types of monoclonal antibody infusions in December because they were ineffective against the omicron variant, and providers had to ration the effective types. New antiviral COVID-19 pills that have received emergency FDA approval are coming in small shipments every other week to Minnesota.

Good news came Tuesday when the state reported its first decline in a month in the positivity rate of COVID-19 testing. Just over 23% of samples were positive in the seven days ending Jan. 14. Modeling by Mayo Clinic suggests a peak is only days away for a pandemic wave that has produced record infections in Minnesota.

A report Tuesday by the Centers for Disease Control and Prevention (CDC) also verified that omicron has produced elevated infections and hospital admissions in the U.S. but shorter hospital stays and fewer intensive care unit admissions and deaths.

Minnesota's experience matches those findings: COVID-19 hospitalizations increased in early January but declined last week and reached 1,507 on Monday. The share of hospitalizations requiring stays in intensive care units also declined from 25% in mid-December to 15%.

The CDC report cautioned that more vaccinations and preventive therapies are needed, because the pandemic continues to threaten hospital capacity and cause COVID-19 deaths.

Minnesota on Tuesday reported 35,504 coronavirus infections and 37 COVID-19 deaths, reflecting pandemic activity over the weekend and some catchup on a backlog of infection reports. While 82% of the state's 11,230 COVID-19 deaths were among seniors, Tuesday's report included the death of a Hennepin County resident age 25-29.

The U trial is enrolling 1,100 patients with COVID-19 to receive fluvoxamine and ivermectin, alone or in combination with metformin, or a nonmedicating placebo for comparison. The study is tracking whether patients taking the drugs for 14 days avoid hospitalization and maintain healthy blood oxygen levels.

Bramante said the drugs have potential to reduce excessive inflammation — a hallmark of some of the most severe and fatal COVID-19 cases. Ivermectin has been tried in other countries, such as India, with less access to vaccine, despite a World Health Organization warning against its use outside clinical trials until its benefits are proven.

Some global studies of the drug have been debunked while others in the U.S. are behind the U study. Duluth-based Essentia Health on Monday announced it was joining the ongoing national ACTIV-6 clinical trial that is studying ivermectin in combination with fluvoxamine and fluticasone, an inhaled steroid.

"The aim of the study is to see if these medications make you feel better sooner and prevent hospitalization," said Dr. Rajesh Prabhu, an Essentia infectious disease specialist.

Bramante is not allowed to see the patient data from the U study until after enrollment is finished, but she said it is a positive sign that a data safety monitoring board has allowed it to continue. That means the drugs aren't causing harm but also there is no proof yet they absolutely work or don't work against COVID-19.

The U has been a national leader in studies to repurpose drugs against COVID-19, launching trials that failed to support the use of hydroxychloroquine for prevention or treatment.

If the COVID-OUT drugs are going to work, Bramante said, they likely need to be taken early in infections. U researchers have been making daily runs to an overnight shipping depot to get study drugs to people with COVID-19 who enroll in less than one day.

Minnesota learned Monday that it will receive a slight increase in proven outpatient treatments. Next week's federal allotment of monoclonal antibodies increased 21% and will include 792 courses of sotrovimab and 1,224 courses of Evusheld, which is mostly limited to COVID-19 patients who are immunocompromised.

Next week's shipment of antiviral pills will be unchanged, with 5,440 doses of molnupiravir and 1,360 doses of the more effective Paxlovid.

M Health Fairview has administered 160 doses of the drugs but has found a 30% refusal rate because people are worried about side effects or don't think their symptoms merit treatment until it is too late, said Dr. Bryan Jarabek, Fairview's chief medical informatics officer.

"People don't realize how sick they're going to get," he said.

Some patients balk at being offered the less effective molnupiravir because the most effective one is being rationed for the highest-risk patients, Jarabek added.

"It is still totally worth it," he said. "It decreases your hospital risk by 30%. It makes you feel better faster."